General state-space population dynamics model for Bayesian stock assessment

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Personality and Dietary Intake - Findings in the Helsinki Birth Cohort Study

Peer reviewe

A Central Role for GRB10 in Regulation of Islet Function in Man

Peer reviewe

A central role for GRB10 in regulation of islet function in man

Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion in different tissues. GRB10 knock-down in human pancreatic islets showed reduced insulin and glucagon secretion, which together with changes in insulin sensitivity may explain the paradoxical reduction of glucose despite a decrease in insulin secretion. Together, these findings suggest that tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism and contribute to T2D pathogenesis. The data also emphasize the need in genetic studies to consider whether risk alleles are inherited from the mother or the father

Linear regressions between nutrients as dependent variables and the personality traits neuroticism, extraversion, openness to experience, agreeableness and conscientiousness as independent variables in men (<i>n</i> = 743).

1<p>Nutrients adjusted for energy using the residual method.</p>2<p>Beta coefficient for the change in nutrient intake (g/d, mg/d, or μg/d) for every 1 SD increase in the personality score.</p>3<p>Model 1 adjusted for age, educational attainment, and total energy intake.</p>4<p>Remained significant after applying Model 2 adjusted for age, educational attainment, total energy intake, BMI and WHR.</p>5<p>Remained significant after applying the Bonferroni corrections.</p><p>Mean difference in food use (g/d) is given for the increase of 1 SD in the personality score.</p

Characteristics of the study population.

1<p>By resilience is meant the personality profile with low neuroticism and high extraversion, openness to experience, agreeableness and conscientiousness.</p

Differences in food intake in resilient women (<i>n</i> = 454) compared to non-resilient women (<i>n</i> = 484).

<p>Values are given as g/d and adjusted for age, educational attainment, and total energy intake. The error bars indicate 95% confidence intervals. Resilience is defined as a personality profile with low neuroticism and high extraversion, openness to experience, agreeableness and conscientiousness. Vegetables do not include potatoes. Fruits include fruits, berries and fruit juices.</p